Roche informed healthcare professionals about revisions made to the prescribing information for Rocephin (Ceftriaxone Sodium) to clarify the potential risk associated with concomitant use of Rocephin with calcium or calcium-containing solutions or products.
Healthcare professionals are advised that Rocephin and calcium-containing solutions including continuous calcium-containing infusions such as parenteral nutrition, should not be mixed or co-administered to any patient irrespective of age, even via different infusion lines at different sites. Rocephin and IV calcium-containing solutions should not be administered within 48 hours of each other in any patient. No data are available on the potential interaction between ceftriaxone and oral calcium-containing products or interaction between intramuscular ceftriaxone and calcium-containing products (IV or oral).
Source: http://www.fda.gov/medwatch/safety/2007/safety07.htm#Rocephin
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