The Annals of Pharmacotherapy describes a case of a patient who developed drug-induced cholestasis after being on risperidone maintenance therapy for 8 years.
A 30-year-old male with schizoaffective disorder, bipolar type, and insulin-dependent diabetes mellitus had been stable on risperidone 6 mg at night for 8 years. His other medications included lithium 900 mg twice daily and enalapril 5 mg daily, as well as regular insulin and NPH insulin as needed. The patient developed cholestasis that resolved once risperidone was discontinued. Over the next 11 months, he tolerated trials of ziprasidone and olanzapine. When quetiapine was initiated, the patient developed signs and symptoms of cholestasis within 3 weeks after starting this medication. The signs and symptoms of cholestasis resolved with removal of quetiapine. The Naranjo probability scale indicated that these atypical antipsychotics (risperidone and quetiapine) were the probable cause of cholestasis in this patient.
Source: Annals of Pharmacotherapy 2007;41(9):1518-1523.
http://www.theannals.com/cgi/content/abstract/41/9/1518
Subscribe to:
Post Comments (Atom)
1 comment:
interesting....
We had one patient, recently on 50 mg BD of quitiapine since a long time. She had presented to us with sever jaundice, the cause of which we not able to make out.
May be it was Quitiapine after all...
Post a Comment