A case of bilateral upper extremity edema associated with Amlodipine use has been reported in the latest issue of The Annals of Pharmacotherapy.
A previously well and normotensive 6-year-old girl presented with a generalized vasculitis of unknown origin and severe hypertension. Large vessels predominantly affecting the neck, chest, and abdomen were found to be involved, resulting in abnormal arterial circulation and significant blood pressure differences between the upper and lower extremities. Multiple antihypertensive agents were initially required to control blood pressure. She was stabilized and discharged on amlodipine 10 mg each evening, atenolol 50 mg/day, and warfarin. Three days later she was noted to have facial and bilateral upper extremity pitting edema. Laboratory and radiologic assessments for possible etiologies were negative. Discontinuation of amlodipine resulted in resolution of edema. According to the Naranjo probability scale, amlodipine was a probable cause of bilateral upper extremity edema in this child.
Source: The Annals of Pharmacotherapy 2007;41(9):1536-38.
http://www.theannals.com/cgi/content/abstract/41/9/1536
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