Convulsions with propofol

A case report of convulsions after propofol administration has been published in Journal of Postgraduate Medicine.
Reference Article: J Postgrad Med 2009;55:69-71
Source: http://www.jpgmonline.com/text.asp?2009/55/1/69/48444

Propofol

FDA informed healthcare professionals about several clusters of patients who experienced chills, fever, and body aches shortly after receiving propofol for sedation or general anesthesia. Multiple vials and several lots of propofol used in patients who experienced these symptoms were tested and there was no evidence that the propofol vials or prefilled syringes used were contaminated with bacteria or endotoxins. Propofol is an intravenous sedative-hypnotic agent for use in the induction and maintenance of anesthesia or sedation.

To minimize the potential for bacterial contamination, propofol vials and prefilled syringes should be used within six hours of opening and one vial should be used for one patient only. Patients who develop fever, chills, body aches or other symptoms of acute febrile reactions shortly after receiving propofol should be evaluated for bacterial sepsis. Healthcare professionals who administer propofol for sedation or general anesthesia should carefully follow the recommendations for handling and use in the product's full prescribing information.

Source: FDA Medwatch
http://www.fda.gov/cder/drug/infopage/propofol/default.htm