Friday, December 28, 2007

Gabapentin Induced Hypersensitivity Syndrome

Hypersensitivity syndrome (HSS) is a rare condition that can occur with any drug. Diagnosis is clinically based, with variable symptoms appearing anywhere between one week to three months after the introduction of the implicated drug. A case of HSS due to gabapentin in a 35 years old lady has been published in the Journal of Postgraduate Medicine.

Naranjo's algorithm, a systematic method of objectively determining the probability of adverse drug reaction having occurred, was applied to this case. A score of 6 was calculated, equating to a "probable" adverse reaction to gabapentin.

Source: J Postgrad Med 2007;53:276-7

http://www.jpgmonline.com/text.asp?2007/53/4/276/37527

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