A case of a 62-year-old male presenting on 3 separate occasions with symptoms consistent with aseptic meningitis: 2 requiring hospitalization and 1 noted during a subsequent ambulatory care visit, has been published in the latest issue of Annals of Pharmacotherapy.
Methotrexate-induced aseptic meningitis has been reported in the literature; however, in those cases, the effect occurred only when methotrexate was given via the intrathecal route. The Naranjo probability scale indicates a probable relationship between the development of the condition and the methotrexate use in this patient.
Source: The Annals of Pharmacotherapy 2007;41(11):1906-1911.
http://www.theannals.com/cgi/content/abstract/41/11/1906
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