A case of a patient who developed marked anxiety associated with episodes of panic attacks after starting rabeprazole therapy has been reported in The Annals of Pharmacotherapy.
An otherwise healthy 55-year-old woman was prescribed rabeprazole 20 mg/day administered in the morning for persistent symptoms of dyspepsia. Ten days later, she presented with a 7 day history of marked anxiety associated with panic attacks, night terror (pavor nocturnus), episodic mental confusion, and attention deficit. Within 2 days of discontinuing rabeprazole, the patient recovered completely from the neuropsychiatric manifestations. Subsequent esomeprazole therapy did not cause psychiatric symptoms.
Source: http://www.theannals.com/cgi/content/abstract/41/7/1315
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